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Force of Despair works awesomely when its cast as a surprise from your hand, and can be game-warping as a loudly broadcast threat in your graveyard

Spells like Grisly Salvage and Mulch can also help as one-off mill effects that add cards to the hand in the meantime

No restrictions, really, no particular format

Chandra, Novice Pyromancer Chandra, Novice Pyromancer is actually decent in formats like a Peasant Cube

A fairly common opening is casting Green Suns Zenith on turn one to find Dryad Arbor a one-mana ramp spell

While Im not sure if it truly makes the cut in cEDH, you could also cast Return the Favor to make your own copy of the enters-the-battlefield ability of Thassas Oracle to win on top of their ability on the stack